MN580 Primary Care of children and Adolescence Health

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MN580 Primary Care of children and Adolescence Health

Description

 

Need below DQ done 300 words APA format no cover needed,, I have started it and included references. Need 3 references with citation Topic is in bold below

Topic 1: Pain Management, Palliative Care, Metabolic, Endocrine, Genetic, and Chronic Conditions and Management Plans

This week, there will be a variety of conditions assigned to you by your instructor pertaining to metabolic, endocrine, genetic, and chronic conditions. You are expected to present your initial topic including, but not limited to, the following items:

  • Pathophysiology
  • Epidemiology
  • Physical exam findings
  • Differential diagnoses and rationale
  • Management plan to include diagnostic testing, medications if applicable, follow-up plans and referrals if needed

In addition, you are required to follow the Discussion Board grading rubric and respond to at least three of your classmates. Topics may include:

    1. Neurofibromatosis

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Neurofibromatosis

 

Physical exam findings t

he earliest clinical finding usually seen in children with NF1 is multiple café-au-lait spots. These may be present at birth or may appear over time, frequently increasing in size and number throughout childhood Subcutaneous or cutaneous neurofibromas are seen rarely in young children but appear over time in older children, adolescents, and adults. MN580 Primary Care of children and Adolescence Health

Differential diagnoses and rationale

Management plan to include diagnostic testing, medications if applicable, follow-up plans and referrals if needed

 

Pathophysiology

The pathophysiology of a neurofibromatosis consists of a protein called the NF1 gene. This protein is known to suppress tumors and serves as a signal regulator or cell proliferation and differentiation. When this protein/gene is interfered with a dysfunction takes place and can affect the regulation and cause uncontrolled cell proliferation. The Schwann cells in neurofibroma’s have a nutation in the NF1 alleles. (Amy (July 2009).)

Epidemiology

According to the “Primary Central Nervous System” (Patrick Y. December, 2016), NF1 occurs in 1 in 3000 individuals and is equally prevalent among men and women and is the most common inherited nervous system disorders and those whom are affected have a reduced life expectancy by 10-15 years than the average person.

 

 

 

Boyd, Kevin P.; Korf, Bruce R.; Theos, Amy (July 2009). “Neurofibromatosis type 1”. Journal of the American Academy of Dermatology. 61 (1): 1–14. doi:10.1016/j.jaad.2008.12.051. PMC 2716546. PMID 19539839.

Norden, Andrew D.; Reardon, David A.; Wen, Patrick Y. (16 December 2010). Primary Central Nervous System Tumors: Pathogenesis and Therapy. Springer Science & Business Media. p. 459. ISBN 9781607611660. Archived from the original on 10 June 2016.

Ferner, R. E., Huson, S. M., Thomas, N., Moss, C., Willshaw, H., Evans, D. G., … Kirby, A. (2007). Guidelines for the diagnosis and management of individuals with neurofibromatosis 1. Journal of medical genetics, 44(2), 81–88. doi:10.1136/jmg.2006.045906

Molecular diagnosis as a strategy for differential diagnosis and at early ages of neurofibromatosis type 1 (NF1)].Gómez M, Batista O.Rev Med Chil. 2015 Oct;143(10):1320-30. doi: 10.4067/S0034-98872015001000011. R. MN580 Primary Care of children and Adolescence Health

https://www.ncbi.nlm.nih.gov/pubmed/23656349